![]() ![]() Tumor diseases: account for 20 - 30% of FUO causes.Infectious diseases: account for 30 - 40% of FUO causes, which is the main cause, such as tuberculosis (especially extrapulmonary tuberculosis), various viral infections, endocarditis, intra-abdominal infections (e.g, liver abscess) and osteomyelitis.About 20-30% of patients with FUO still cannot be diagnosed in the end. This kind of fever is called fever of unknown origin (FUO). ![]() Only a few fever patients cannot find out the cause even after detailed examination. Most fever lasts for up to 1-2 weeks and will automatically abate or the cause of fever will be quickly detected. Common infections include urinary tract infections, pneumonia, tuberculosis, endocarditis, osteomyelitis (infection of the bone), tick-borne diseases (e.g., Lyme disease), gonorrhea, syphilis, herpes, HIV, AIDS, and abdominal abscesses.Fever is a common manifestation of many diseases. DON’T forget that infection is the main cause of FUO.Follow the instructions of your health care provider and specialists. About 5% to 15% of cases don’t have a diagnosis. DO call your health care provider if you have symptoms that may help make the diagnosis (e.g., cough, sputum production, shortness of breath, abdominal pain, diarrhea, bloody stools, muscle aches, joint aches, joint swelling, bone pain, or burning with urination).DO call your health care provider if you have a longlasting fever (101° F or higher).DO report any new symptoms if you are being evaluated for FUO.If the FUO remains undiagnosed, your health care provider may just watch for more symptoms. DO remember that your health care provider won’t usually start using medicines without making a diagnosis.For a collagenvascular disease, a rheumatologist (a doctor specializing in joint and collagen-vascular diseases) will help. If a tumor is found, an oncologist (a doctor specializing in cancer treatment) will be involved. Antibiotics will be given for infections. ![]() A doctor who specializes in infections will help with diagnosis, evaluation, and treatment of infectious diseases. The disease causing the fever must be treated. If endocarditis may be the cause, echocardiography (an ultrasound test using sound waves to take pictures of the heart) will be done. If the diagnosis remains unclear, the health care provider may order imaging studies, such as x-rays and computed tomography (CT) of the chest, abdomen (belly), and pelvis. How Is FUO Diagnosed?Īs part of the evaluation, the health care provider will take a detailed history, do a physical examination, and order blood tests. ![]() The medical definition describes the symptom: a temperature of 101° F (38.3° C) for more than 3 weeks and no diagnosis after 1 week of evaluation. Other rare causes of FUO are drugs such as antibiotics, antihistamines, antiseizure drugs, antiinflammatory drugs, and medicines used for acid reflux and peptic ulcers. In older people, it’s inflammation of the temporal artery, found at the temple region of the head. The most common collagen-vascular disease in young people is juvenile rheumatoid arthritis. Other tumors are leukemia, multiple myeloma, and renal, liver, colon, and breast cancers. Tumors, the second most common cause, include Hodgkin’s and non- Hodgkin’s lymphomas. Infections, the most common cause, include endocarditis (infection of the heart’s lining or valves), tuberculosis, abscesses, and viral infections such as cytomegalovirus infection. They’re caused by the body’s immune (infection-fighting) system attacking its own organs. Collagen-vascular diseases include systemic lupus, rheumatoid arthritis, and scleroderma. Three major causes are infections, tumors, and collagen vascular diseases. Fever of unknown origin (FUO), as its name says, is a high temperature without any known cause after diagnostic tests have been done. ![]()
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